Metazoan complexes |
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Emili & Marcotte labs |
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Details of DPYD gene in Homo sapiens
IDs | |||||||||
---|---|---|---|---|---|---|---|---|---|
Link outs | Gene Name | Alias | Uniprot ID | SwissProt ID | NCBI gene ID | ENSEMBL ID | Description | Source | |
| DPYD | --- | Q12882 | DPYD_HUMAN | 1806 | ENSG00000188641 | Dihydropyrimidine dehydrogenase [NADP(+)] | SPROT |
Disease | |||||||||
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Disease | OMIM id | ||||||||
Dihydropyrimidine dehydrogenase deficiency (DPYDD) [MIM:274270]: A metabolic disorder with large phenotypic variability, ranging from no symptoms to a convulsive disorder with motor and mental retardation. It is characterized by persistent urinary excretion of excessive amounts of uracil, thymine and 5-hydroxymethyluracil. Patients suffering from this disease show a severe reaction to the anticancer drug 5- fluorouracil. Note=The disease is caused by mutations affecting the gene represented in this entry. | 274270 |
Orthologs in other species | |||||||||
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M. musculus | D. melonogaster | C. elegans | S. purpuratus | ||||||
Dpyd | su(r) | dpyd-1 | Sp-Dpyd |
Conserved gene 1 |
Conserved gene 2 |
Conserved score |
H. sapiens gene 1 |
H. sapiens gene 2 |
Complex ID | Corum | BioGrid | IRefWeb | Novelty |
---|---|---|---|---|---|---|---|---|---|