Metazoan Gene Interaction Project

	Metazoan complexes
	Emili & Marcotte labs

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H.sapiens
M.musculus
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Details of FUS gene in Homo sapiens

IDs
Link outs	Gene Name	Alias	Uniprot ID	SwissProt ID	NCBI gene ID	ENSEMBL ID	Description	Source
	FUS	TLS	P35637	FUS_HUMAN	2521	ENSG00000089280	RNA-binding protein FUS	SPROT

Disease
Disease	OMIM id
Note=A chromosomal aberration involving FUS is found in a patient with malignant myxoid liposarcoma. Translocation t(1216)(q13p11) with DDIT3.	---
Note=A chromosomal aberration involving FUS is a cause of acute myeloid leukemia (AML). Translocation t(1621)(p11q22) with ERG.	---
Angiomatoid fibrous histiocytoma (AFH) [MIM:612160]: A distinct variant of malignant fibrous histiocytoma that typically occurs in children and adolescents and is manifest by nodular subcutaneous growth. Characteristic microscopic features include lobulated sheets of histiocyte-like cells intimately associated with areas of hemorrhage and cystic pseudovascular spaces, as well as a striking cuffing of inflammatory cells, mimicking a lymph node metastasis. Note=The disease may be caused by mutations affecting the gene represented in this entry. A chromosomal aberration involving FUS is found in a patient with angiomatoid fibrous histiocytoma. Translocation t(1216)(q13p11.2) with ATF1 generates a chimeric FUS/ATF1 protein.	612160
Amyotrophic lateral sclerosis 6 (ALS6) [MIM:608030]: A neurodegenerative disorder affecting upper motor neurons in the brain and lower motor neurons in the brain stem and spinal cord, resulting in fatal paralysis. Sensory abnormalities are absent. The pathologic hallmarks of the disease include pallor of the corticospinal tract due to loss of motor neurons, presence of ubiquitin-positive inclusions within surviving motor neurons, and deposition of pathologic aggregates. The etiology of amyotrophic lateral sclerosis is likely to be multifactorial, involving both genetic and environmental factors. The disease is inherited in 5- 10% of the cases. Note=The disease is caused by mutations affecting the gene represented in this entry.	608030
Tremor, hereditary essential 4 (ETM4) [MIM:614782]: A common movement disorder mainly characterized by postural tremor of the arms. Head, legs, trunk, voice, jaw, and facial muscles also may be involved. The condition can be aggravated by emotions, hunger, fatigue and temperature extremes, and may cause a functional disability or even incapacitation. Inheritance is autosomal dominant. Note=The disease is caused by mutations affecting the gene represented in this entry.	614782

Orthologs in other species
M. musculus	D. melonogaster	C. elegans	S. purpuratus
Fus	caz	fust-1	Sp-Ewsr1L

Conserved gene 1	Conserved gene 2	Conserved score	H. sapiens gene 1	H. sapiens gene 2	Complex ID	Corum	BioGrid	IRefWeb	Novelty
PTBP1	FUS	0.097773865	PTBP1	FUS	cpx874	no	no	no	Novel
FUS	HNRNPD	0.231510437	FUS	HNRNPD	cpx337; cpx319	no	no	no	Novel
FUS	NONO	0.164748346	FUS	NONO	cpx827	no	yes	no	Known
FUS	PGK1	0.444501842	FUS	PGK1	cpx338; cpx319	no	no	no	Novel
FUS	HNRNPA3	0.366365955	FUS	HNRNPA3	cpx319	no	yes	no	Known
FUS	HNRNPAB	0.032679171	FUS	HNRNPAB	cpx337	no	no	no	Novel
FUS	SFPQ	0.093929323	FUS	SFPQ	cpx880	no	yes	yes	Known

Conserved gene 1	Conserved gene 2	Conserved score	H. sapiens gene 1	H. sapiens gene 2
FUS	DNAJC7	0.173076406	FUS	DNAJC7
FUS	C2orf49	0.082373454	FUS	C2orf49
FUS	EIF4H	0.101933718	FUS	EIF4H
TOMM34	FUS	0.12651638	TOMM34	FUS
FUS	ARMC1	0.169881588	FUS	ARMC1
FUS	TARS	0.07021585	FUS	TARS
FUS	MEF2D	0.097334646	FUS	MEF2D
FUS	ACAT1	0.086085161	FUS	ACAT1
AURKA	FUS	0.114189874	AURKA	FUS
FUS	HNRPDL	0.204222125	FUS	HNRPDL
FUS	PICALM	0.203326675	FUS	PICALM
FUS	DDX17	0.102545858	FUS	DDX17
FUS	PFKP	0.088540443	FUS	PFKP
FUS	NAA50	0.191469606	FUS	NAA50
FUS	NPLOC4	0.092535185	FUS	NPLOC4
TXLNA	FUS	0.115139015	TXLNA	FUS
FUS	HNRNPL	0.23868211	FUS	HNRNPL
UFD1L	FUS	0.089318209	UFD1L	FUS

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