Metazoan complexes |
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Emili & Marcotte labs |
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Details of IDH1 gene in Homo sapiens
IDs | |||||||||
---|---|---|---|---|---|---|---|---|---|
Link outs | Gene Name | Alias | Uniprot ID | SwissProt ID | NCBI gene ID | ENSEMBL ID | Description | Source | |
| IDH1 | PICD | O75874 | IDHC_HUMAN | 3417 | ENSG00000138413 | Isocitrate dehydrogenase [NADP] cytoplasmic | SPROT |
Disease | |||||||||
---|---|---|---|---|---|---|---|---|---|
Disease | OMIM id | ||||||||
Glioma (GLM) [MIM:137800]: Gliomas are benign or malignant central nervous system neoplasms derived from glial cells. They comprise astrocytomas and glioblastoma multiforme that are derived from astrocytes, oligodendrogliomas derived from oligodendrocytes and ependymomas derived from ependymocytes. Note=The gene represented in this entry is involved in disease pathogenesis. Mutations affecting Arg-132 are tissue-specific, and suggest that this residue plays a unique role in the development of high-grade gliomas. Mutations of Arg-132 to Cys, His, Leu or Ser abolish magnesium binding and abolish the conversion of isocitrate to alpha-ketoglutarate. Instead, alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate. Elevated levels of R(-)-2- hydroxyglutarate are correlated with an elevated risk of malignant brain tumors. | 137800 |
Orthologs in other species | |||||||||
---|---|---|---|---|---|---|---|---|---|
M. musculus | D. melonogaster | C. elegans | S. purpuratus | ||||||
Idh1 | Idh | idh-1 | Sp-Idh1 |
Conserved gene 1 |
Conserved gene 2 |
Conserved score |
H. sapiens gene 1 |
H. sapiens gene 2 |
Complex ID | Corum | BioGrid | IRefWeb | Novelty |
---|---|---|---|---|---|---|---|---|---|
IDH1 | DAZAP1 | 0.267956015 | IDH1 | DAZAP1 | cpx204; cpx2 | no | no | no | Novel |
IDH1 | FH | 0.058715976 | IDH1 | FH | cpx2 | no | no | no | Novel |
ARF4 | IDH1 | 0.118166741 | ARF4 | IDH1 | cpx204; cpx2 | no | no | no | Novel |
GLOD4 | IDH1 | 0.053665508 | GLOD4 | IDH1 | cpx2 | no | no | no | Novel |
IDH2 | IDH1 | 0.268537849 | IDH2 | IDH1 | cpx126 | no | no | no | Novel |
IDH3G | IDH1 | 0.217553897 | IDH3G | IDH1 | cpx126 | no | no | no | Novel |
IDH3B | IDH1 | 0.106425632 | IDH3B | IDH1 | cpx126 | no | no | no | Novel |
IDH3A | IDH1 | 0.339753359 | IDH3A | IDH1 | cpx126 | no | no | no | Novel |
IDH1 | PCBP1 | 0.165857828 | IDH1 | PCBP1 | cpx2 | no | no | no | Novel |
IDH1 | ACP1 | 0.03985853 | IDH1 | ACP1 | cpx2 | no | no | no | Novel |
IDH1 | PRDX2 | 0.026152728 | IDH1 | PRDX2 | cpx2 | no | no | no | Novel |