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Metazoan complexes |
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Details of KYNU gene in Homo sapiens
IDs | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Link outs | Gene Name | Alias | Uniprot ID | SwissProt ID | NCBI gene ID | ENSEMBL ID | Description | Source | |
|
| KYNU | --- | Q16719 | KYNU_HUMAN | 8942 | ENSG00000115919 | Kynureninase | SPROT | |
Disease | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Disease | OMIM id | ||||||||
| Note=Xanthurenic aciduria manifesting as massive urinary excretion of large amounts of kynurenine, 3-hydroxykynurenine and xanthurenic acid has been observed in an individual carrying a homozygous missense change in KYNU (PubMed:17334708). The urinary pattern in the patient suggests kynureninase deficiency and a block in the conversion of kynurenine and 3-hydroxykynurenine to anthranilate and 3-hydroxyanthranilate, respectively. | --- | ||||||||
Orthologs in other species | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| M. musculus | D. melonogaster | C. elegans | S. purpuratus | ||||||
| Kynu | --- | C15H9.7 | Sp-Kynu | ||||||
| Conserved gene 1 |
Conserved gene 2 |
Conserved score |
H. sapiens gene 1 |
H. sapiens gene 2 |
Complex ID | Corum | BioGrid | IRefWeb | Novelty |
|---|---|---|---|---|---|---|---|---|---|
| KYNU | ADK | 0.156478913 | KYNU | ADK | cpx149 | no | no | no | Novel |
| KYNU | ASS1 | 0.542972221 | KYNU | ASS1 | cpx149 | no | no | no | Novel |
| KYNU | CFL1 | 0.130802499 | KYNU | CFL1 | cpx174 | no | no | no | Novel |
| KYNU | DSTN | 0.18923237 | KYNU | DSTN | cpx267 | no | no | no | Novel |
| MTAP | KYNU | 0.065191231 | MTAP | KYNU | cpx149 | no | no | no | Novel |
| KYNU | PPIA | 0.105676971 | KYNU | PPIA | cpx174 | no | no | no | Novel |