Metazoan Gene Interaction Project

	Metazoan complexes
	Emili & Marcotte labs

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IDs
Link outs	Gene Name	Alias	Uniprot ID	SwissProt ID	NCBI gene ID	ENSEMBL ID	Description	Source
	MT-CO2	COII,COXII,MTCO2	P00403	COX2_HUMAN	4513	ENSG00000198712	Cytochrome c oxidase subunit 2	SPROT

Disease
Disease	OMIM id
Mitochondrial complex IV deficiency (MT-C4D) [MIM:220110]: A disorder of the mitochondrial respiratory chain with heterogeneous clinical manifestations, ranging from isolated myopathy to severe multisystem disease affecting several tissues and organs. Features include hypertrophic cardiomyopathy, hepatomegaly and liver dysfunction, hypotonia, muscle weakness, exercise intolerance, developmental delay, delayed motor development and mental retardation. Some affected individuals manifest a fatal hypertrophic cardiomyopathy resulting in neonatal death. A subset of patients manifest Leigh syndrome. Note=The disease is caused by mutations affecting the gene represented in this entry.	220110

Orthologs in other species
M. musculus	D. melonogaster	C. elegans	S. purpuratus
Mtco2	mt:CoII	cox-2	---

Conserved gene 1	Conserved gene 2	Conserved score	H. sapiens gene 1	H. sapiens gene 2	Complex ID	Corum	BioGrid	IRefWeb	Novelty
CLTC	MT-CO2	0.259653278	CLTC	MT-CO2	cpx20; cpx7	no	no	no	Novel
ABCC1	MT-CO2	0.032094429	ABCC1	MT-CO2	cpx7	no	no	no	Novel
SLC25A3	MT-CO2	0.200404598	SLC25A3	MT-CO2	cpx20	no	no	no	Novel
CYC1	MT-CO2	0.058771226	CYC1	MT-CO2	cpx20	no	yes	no	Known
TUFM	MT-CO2	0.065454761	TUFM	MT-CO2	cpx20	no	no	no	Novel
RAB1B	MT-CO2	0.456463645	RAB1B	MT-CO2	cpx7	no	no	no	Novel
HSP90B1	MT-CO2	0.084474495	HSP90B1	MT-CO2	cpx7	no	no	no	Novel
RPN1	MT-CO2	0.230115226	RPN1	MT-CO2	cpx7	no	no	no	Novel
ATP1A1	MT-CO2	0.061812013	ATP1A1	MT-CO2	cpx7	no	no	no	Novel
TECR	MT-CO2	0.050595523	TECR	MT-CO2	cpx7	no	no	no	Novel
ATP5C1	MT-CO2	0.20177436	ATP5C1	MT-CO2	cpx7	no	no	no	Novel
CANX	MT-CO2	0.138600401	CANX	MT-CO2	cpx7; cpx20	no	no	no	Novel
MT-CO2	COX4I1	0.240917555	MT-CO2	COX4I1	cpx30	no	no	no	Novel
MT-CO2	DDOST	0.072473383	MT-CO2	DDOST	cpx7; cpx30	no	no	no	Novel
MT-CO2	PHB2	0.02774319	MT-CO2	PHB2	cpx30	no	no	no	Novel
MT-CO2	PHB	0.200401246	MT-CO2	PHB	cpx30	no	yes	yes	Known
MT-CO2	UQCRC2	0.847943308	MT-CO2	UQCRC2	cpx20; cpx7	no	no	no	Novel
MT-CO2	SSR1	0.174569595	MT-CO2	SSR1	cpx20	no	no	no	Novel
MT-CO2	SSR4	0.203149436	MT-CO2	SSR4	cpx7	no	no	no	Novel
MT-CO2	VDAC1	0.241253244	MT-CO2	VDAC1	cpx30	no	no	no	Novel
MT-CO2	VDAC2	0.201029747	MT-CO2	VDAC2	cpx30	no	no	no	Novel
MT-CO2	VDAC3	0.227827923	MT-CO2	VDAC3	cpx30	no	no	no	Novel

Conserved gene 1	Conserved gene 2	Conserved score	H. sapiens gene 1	H. sapiens gene 2
NDUFV2	MT-CO2	0.07287918	NDUFV2	MT-CO2
ATP5F1	MT-CO2	0.154681189	ATP5F1	MT-CO2
NDUFS1	MT-CO2	0.091761078	NDUFS1	MT-CO2
ATP2B3	MT-CO2	0.093155464	ATP2B3	MT-CO2
GPD2	MT-CO2	0.091304347	GPD2	MT-CO2
COX5B	MT-CO2	0.07506709	COX5B	MT-CO2
MT-CO2	MAGT1	0.104130125	MT-CO2	MAGT1
SDHB	MT-CO2	0.143048654	SDHB	MT-CO2

Metazoan complexes