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Metazoan complexes |
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H.sapiens
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Details of MTHFD1 gene in Homo sapiens
IDs | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Link outs | Gene Name | Alias | Uniprot ID | SwissProt ID | NCBI gene ID | ENSEMBL ID | Description | Source | |
|
| MTHFD1 | MTHFC,MTHFD | P11586 | C1TC_HUMAN | 4522 | ENSG00000100714 | C-1-tetrahydrofolate synthase, cytoplasmic Methylenetetrahydrofolate dehydrogenase Methenyltetrahydrofolate cyclohydrolase Formyltetrahydrofolate synthetase | SPROT | |
Disease | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Disease | OMIM id | ||||||||
| Folate-sensitive neural tube defects (FS-NTD) [MIM:601634]: The most common NTDs are open spina bifida (myelomeningocele) and anencephaly. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry. | 601634 | Colorectal cancer (CRC) [MIM:114500]: A complex disease characterized by malignant lesions arising from the inner wall of the large intestine (the colon) and the rectum. Genetic alterations are often associated with progression from premalignant lesion (adenoma) to invasive adenocarcinoma. Risk factors for cancer of the colon and rectum include colon polyps, long-standing ulcerative colitis, and genetic family history. Note=Disease susceptibility may be associated with variations affecting the gene represented in this entry. | 114500 | ||||||
Orthologs in other species | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| M. musculus | D. melonogaster | C. elegans | S. purpuratus | ||||||
| Mthfd1 | pug | K07E3.4 | Sp-Mthfd1 | ||||||
| Conserved gene 1 |
Conserved gene 2 |
Conserved score |
H. sapiens gene 1 |
H. sapiens gene 2 |
Complex ID | Corum | BioGrid | IRefWeb | Novelty |
|---|---|---|---|---|---|---|---|---|---|
| HNRNPA1 | MTHFD1 | 0.064879887 | HNRNPA1 | MTHFD1 | cpx942 | no | no | no | Novel |
| PHGDH | MTHFD1 | 0.087665111 | PHGDH | MTHFD1 | cpx962 | no | no | no | Novel |
| Conserved gene 1 |
Conserved gene 2 |
Conserved score |
H. sapiens gene 1 |
H. sapiens gene 2 |
|---|---|---|---|---|
| MTHFD1 | UBA1 | 0.088657292 | MTHFD1 | UBA1 |
| CNN1 | MTHFD1 | 0.144479264 | CNN1 | MTHFD1 |
| NLE1 | MTHFD1 | 0.079435102 | NLE1 | MTHFD1 |
| MTHFD1 | PFKL | 0.098499784 | MTHFD1 | PFKL |
| ABCF2 | MTHFD1 | 0.249072622 | ABCF2 | MTHFD1 |
| MTHFD1 | RPL35A | 0.073264928 | MTHFD1 | RPL35A |
| MTHFD1 | PRPF19 | 0.075048823 | MTHFD1 | PRPF19 |
| MTHFD1 | SAR1A | 0.096425007 | MTHFD1 | SAR1A |
| MTHFD1 | XPNPEP1 | 0.072208036 | MTHFD1 | XPNPEP1 |
| PFKP | MTHFD1 | 0.088106084 | PFKP | MTHFD1 |
| EIF3G | MTHFD1 | 0.107631135 | EIF3G | MTHFD1 |
| MTHFD1 | RPL7 | 0.117925118 | MTHFD1 | RPL7 |
| MTHFD1 | PAPOLA | 0.149769462 | MTHFD1 | PAPOLA |
| RPLP0 | MTHFD1 | 0.076874538 | RPLP0 | MTHFD1 |