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Details of PARK7 gene in Homo sapiens
IDs | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Link outs | Gene Name | Alias | Uniprot ID | SwissProt ID | NCBI gene ID | ENSEMBL ID | Description | Source | |
|
| PARK7 | --- | Q99497 | PARK7_HUMAN | 11315 | ENSG00000116288 | Protein DJ-1 | SPROT | |
Disease | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Disease | OMIM id | ||||||||
| Parkinson disease 7 (PARK7) [MIM:606324]: A neurodegenerative disorder characterized by resting tremor, postural tremor, bradykinesia, muscular rigidity, anxiety and psychotic episodes. PARK7 has onset before 40 years, slow progression and initial good response to levodopa. Some patients may show traits reminiscent of amyotrophic lateral sclerosis- parkinsonism/dementia complex (Guam disease). Note=The disease is caused by mutations affecting the gene represented in this entry. | 168600;606324 | ||||||||
Phenotypes
Abnormal emotion/affect behavior, Abnormal fear/anxiety-related behavior, Abnormality of central motor function, Abnormality of extrapyramidal motor function, Abnormality of head and neck, Abnormality of higher mental function, Abnormality of movement, Abnormality of the central nervous system, Abnormality of the eyelid, Abnormality of the face, Abnormality of the head, Abnormality of the nervous system, Abnormality of the ocular region, Abnormality of the periorbital region, Adult onset, Age of onset, All, Anxiety, Autosomal recessive inheritance, Behavioural/Psychiatric Abnormality, Blepharospasm, Bradykinesia, Dystonia, Focal dystonia, Infantile onset, Mode of inheritance, Onset, Onset and clinical course, Pace of progression, Phenotypic abnormality, Postural tremor, Psychosis, Psychotic episodes, Resting tremor, Rigidity, Slow progression, Tremor.
Orthologs in other species | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| M. musculus | D. melonogaster | C. elegans | S. purpuratus | ||||||
| Park7 | DJ-1alpha... | djr-1.1... | Sp-Dj1p | ||||||
| Conserved gene 1 |
Conserved gene 2 |
Conserved score |
H. sapiens gene 1 |
H. sapiens gene 2 |
Complex ID | Corum | BioGrid | IRefWeb | Novelty |
|---|---|---|---|---|---|---|---|---|---|
| PARK7 | ANXA7 | 0.113514128 | PARK7 | ANXA7 | cpx958 | no | no | no | Novel |
| PARK7 | ENO1 | 0.290064452 | PARK7 | ENO1 | cpx50; cpx40 | no | no | no | Novel |
| PARK7 | MIF | 0.164636905 | PARK7 | MIF | cpx958; cpx40; cpx50 | no | no | no | Novel |
| NIT2 | PARK7 | 0.116127287 | NIT2 | PARK7 | cpx40 | no | no | no | Novel |
| HINT1 | PARK7 | 0.099866503 | HINT1 | PARK7 | cpx873 | no | no | no | Novel |
| PRDX5 | PARK7 | 0.071613065 | PRDX5 | PARK7 | cpx923 | no | yes | no | Known |
| LDHA | PARK7 | 0.148762344 | LDHA | PARK7 | cpx50; cpx40 | no | no | no | Novel |
| LDHB | PARK7 | 0.082453466 | LDHB | PARK7 | cpx40 | no | no | no | Novel |
| PIR | PARK7 | 0.113665491 | PIR | PARK7 | cpx958 | no | no | no | Novel |
| CAT | PARK7 | 0.028903398 | CAT | PARK7 | cpx40 | no | no | no | Novel |
| PARK7 | PDCD6IP | 0.048061774 | PARK7 | PDCD6IP | cpx50 | no | no | no | Novel |
| PARK7 | PRDX6 | 0.065155689 | PARK7 | PRDX6 | cpx940 | no | no | no | Novel |