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Details of ROS1 gene in Homo sapiens
IDs |
Link outs |
Gene Name |
Alias |
Uniprot ID |
SwissProt ID |
NCBI gene ID |
ENSEMBL ID |
Description |
Source |
| ROS1 | MCF3,ROS | P08922 | ROS1_HUMAN | 6098 | ENSG00000047936 | Proto-oncogene tyrosine-protein kinase ROS | SPROT |
Disease |
Disease |
OMIM id |
Note=A chromosomal aberration involving ROS1 is found in a glioblastoma multiforme sample. An intra-chromosomal deletion del(6)(q21q21) is responsible for the formation of GOPC-ROS1 chimeric protein which is localized to the Golgi and has a constitutive receptor tyrosine kinase activity. A SLC34A2-ROS1 chimeric protein produced in non-small cell lung cancer cells also retains a constitutive kinase activity. A third type of chimeric protein CD74-ROS1 was also identified in those cells. |
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Orthologs in other species |
M. musculus |
D. melonogaster |
C. elegans |
S. purpuratus |
Ros1 | sev | rol-3 | --- |