Metazoan Gene Interaction Project

	Metazoan complexes
	Emili & Marcotte labs

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IDs
Link outs	Gene Name	Alias	Uniprot ID	SwissProt ID	NCBI gene ID	ENSEMBL ID	Description	Source
	SOD1	---	P00441	SODC_HUMAN	6647	ENSG00000142168	Superoxide dismutase [Cu-Zn]	SPROT

Disease
Disease	OMIM id
Amyotrophic lateral sclerosis 1 (ALS1) [MIM:105400]: A neurodegenerative disorder affecting upper motor neurons in the brain and lower motor neurons in the brain stem and spinal cord, resulting in fatal paralysis. Sensory abnormalities are absent. The pathologic hallmarks of the disease include pallor of the corticospinal tract due to loss of motor neurons, presence of ubiquitin-positive inclusions within surviving motor neurons, and deposition of pathologic aggregates. The etiology of amyotrophic lateral sclerosis is likely to be multifactorial, involving both genetic and environmental factors. The disease is inherited in 5- 10% of the cases. Note=The disease is caused by mutations affecting the gene represented in this entry.	105400

Orthologs in other species
M. musculus	D. melonogaster	C. elegans	S. purpuratus
Sod1	Sod	sod-1... sod-5	Sp-Sod

Conserved gene 1	Conserved gene 2	Conserved score	H. sapiens gene 1	H. sapiens gene 2	Complex ID	Corum	BioGrid	IRefWeb	Novelty
SOD1	GOT1	0.990266802	SOD1	GOT1	cpx5; cpx77	no	yes	no	Known
SOD1	DBI	0.129875959	SOD1	DBI	cpx955	no	no	no	Novel
SOD1	ADH5	0.063979089	SOD1	ADH5	cpx944	no	no	no	Novel
SOD1	ADK	0.239101905	SOD1	ADK	cpx955	no	no	no	Novel
SOD1	AKR1A1	0.178461825	SOD1	AKR1A1	cpx43	no	no	no	Novel
SOD1	AKR1B1	0.27854835	SOD1	AKR1B1	cpx805	no	no	no	Novel
SOD1	ATOX1	0.15177668	SOD1	ATOX1	cpx955	no	no	no	Novel
SOD1	CAT	0.424741889	SOD1	CAT	cpx5; cpx60	no	no	no	Novel
SOD1	HSPE1	0.804195092	SOD1	HSPE1	cpx77	no	no	no	Novel
SOD1	C11orf54	0.085931488	SOD1	C11orf54	cpx897	no	no	no	Novel
SOD1	CFL1	0.865954522	SOD1	CFL1	cpx5	no	no	no	Novel
SOD1	CFL2	0.424656077	SOD1	CFL2	cpx5	no	no	no	Novel
SOD1	CRIP1	0.220370302	SOD1	CRIP1	cpx5	no	no	no	Novel
SOD1	DSTN	0.264651982	SOD1	DSTN	cpx5	no	no	no	Novel
SOD1	ENO1	0.5	SOD1	ENO1	cpx791	no	yes	no	Known
SOD1	ENO3	0.183780353	SOD1	ENO3	cpx823	no	yes	no	Known
SOD1	ENO2	0.15863717	SOD1	ENO2	cpx832	no	yes	no	Known
SOD1	FABP7	0.724287566	SOD1	FABP7	cpx43	no	no	no	Novel
SOD1	FKBP1A	0.990324124	SOD1	FKBP1A	cpx5	no	yes	yes	Known
SOD1	FKBP1B	0.970733889	SOD1	FKBP1B	cpx744	no	yes	yes	Known
SOD1	GAPDH	0.13643441	SOD1	GAPDH	cpx845	no	no	no	Novel
SOD1	HAGH	0.063790926	SOD1	HAGH	cpx955	no	no	no	Novel
SOD1	GLOD4	1	SOD1	GLOD4	cpx43; cpx77	no	yes	no	Known
SOD1	GLRX	0.253928056	SOD1	GLRX	cpx43	no	no	no	Novel
SOD1	GPX4	0.608970763	SOD1	GPX4	cpx5	no	no	no	Novel
SOD1	LDHA	0.567973918	SOD1	LDHA	cpx60	no	no	no	Novel
SOD1	LDHB	0.14158364	SOD1	LDHB	cpx5	no	no	no	Novel
SOD1	MDH2	0.398323913	SOD1	MDH2	cpx5	no	no	no	Novel
SOD1	NME2	0.999999508	SOD1	NME2	cpx701	no	yes	no	Known
SOD1	NEDD8	0.067263891	SOD1	NEDD8	cpx955	no	no	no	Novel
SOD1	PCBP1	0.537336223	SOD1	PCBP1	cpx77; cpx43	no	no	no	Novel
SOD1	PDCD6IP	0.464917216	SOD1	PDCD6IP	cpx60	no	no	no	Novel
SOD1	PEBP1	0.812416634	SOD1	PEBP1	cpx5	no	no	no	Novel
SOD1	PGM1	0.693976931	SOD1	PGM1	cpx60	no	no	no	Novel
SOD1	PCMT1	0.100669717	SOD1	PCMT1	cpx955	no	no	no	Novel
SOD1	PPIA	0.121913029	SOD1	PPIA	cpx5	no	yes	no	Known
SOD1	PPIF	0.634836409	SOD1	PPIF	cpx955	no	yes	no	Known
SOD1	PRDX1	0.101899302	SOD1	PRDX1	cpx871	no	yes	no	Known
SOD1	PRDX2	0.55001524	SOD1	PRDX2	cpx789	no	yes	no	Known
SOD1	PRDX6	0.061948639	SOD1	PRDX6	cpx952	no	no	no	Novel
SOD1	ADSS	0.028220551	SOD1	ADSS	cpx5	no	no	no	Novel
SOD1	RGN	0.958164078	SOD1	RGN	cpx955	no	yes	no	Known
SRI	SOD1	0.119277996	SRI	SOD1	cpx856	no	no	no	Novel
DAZAP1	SOD1	0.197260082	DAZAP1	SOD1	cpx5; cpx43	no	no	no	Novel
WDR1	SOD1	0.029119272	WDR1	SOD1	cpx5	no	no	no	Novel
TXN	SOD1	0.940339874	TXN	SOD1	cpx763	no	yes	no	Known
PIR	SOD1	0.120840578	PIR	SOD1	cpx77	no	no	no	Novel
SOD1	SOD2	0.984402395	SOD1	SOD2	cpx5; cpx60	no	yes	no	Known
SOD1	TAGLN2	0.07938601	SOD1	TAGLN2	cpx909	no	yes	no	Known
SOD1	TKTL2	0.729371006	SOD1	TKTL2	cpx955	no	no	no	Novel
SOD1	TKT	0.994111652	SOD1	TKT	cpx43; cpx5	no	no	no	Novel
SOD1	TANGO2	0.916185818	SOD1	TANGO2	cpx955	no	yes	no	Known
SOD1	UBE2L3	0.444100418	SOD1	UBE2L3	cpx77	no	no	no	Novel
SOD1	UFC1	0.169142798	SOD1	UFC1	cpx955	no	no	no	Novel
SOD1	UFM1	0.131752913	SOD1	UFM1	cpx5	no	no	no	Novel
SOD1	NME1-NME2	0.999999589	SOD1	NME1-NME2	cpx700	no	yes	no	Known

Conserved gene 1	Conserved gene 2	Conserved score	H. sapiens gene 1	H. sapiens gene 2
SOD1	OAT	0.116067231	SOD1	OAT
SOD1	HSPA9	0.676170198	SOD1	HSPA9
SOD1	COX17	0.259094076	SOD1	COX17
SOD1	QDPR	0.087563419	SOD1	QDPR
SOD1	RAE1	0.074592652	SOD1	RAE1
SOD1	LDHAL6B	0.56576067	SOD1	LDHAL6B
OXCT1	SOD1	0.093387659	OXCT1	SOD1
SOD1	PGM5	0.334542418	SOD1	PGM5
SOD1	NME1	0.174466572	SOD1	NME1
PIN1	SOD1	0.2657132	PIN1	SOD1
SOD1	PRDX5	0.697477458	SOD1	PRDX5
SOD1	NUTF2	0.271992833	SOD1	NUTF2
SOD1	HIBCH	0.167786402	SOD1	HIBCH
SOD1	SPR	0.102304519	SOD1	SPR
SOD1	FABP5	0.481322964	SOD1	FABP5
SOD1	PDXK	0.079521108	SOD1	PDXK
SOD1	SORD	0.079597237	SOD1	SORD
SOD1	PABPC4	0.107633485	SOD1	PABPC4
SOD1	PPIL3	0.070246905	SOD1	PPIL3
SOD1	SERPINB5	0.072068481	SOD1	SERPINB5
SOD1	UBE2V1	0.111689037	SOD1	UBE2V1
CBFB	SOD1	0.253615028	CBFB	SOD1
SOD1	ASNS	0.111686861	SOD1	ASNS
SOD1	CCS	0.147772476	SOD1	CCS
SOD1	RPE	0.110304284	SOD1	RPE
NUDC	SOD1	0.104005914	NUDC	SOD1
SOD1	LGALS1	0.085024075	SOD1	LGALS1
TXN2	SOD1	0.25053298	TXN2	SOD1
SOD1	GNPDA2	0.138839494	SOD1	GNPDA2
SOD1	PGAM1	0.12278113	SOD1	PGAM1
SOD1	LDHC	0.48401876	SOD1	LDHC
SOD1	TRAP1	0.08353226	SOD1	TRAP1
SOD1	SCYL2	0.197427736	SOD1	SCYL2
SOD1	FABP3	0.474928953	SOD1	FABP3
SOD1	AKR1C2	0.223181463	SOD1	AKR1C2
SOD1	AK2	0.202272069	SOD1	AK2
SOD1	PITPNB	0.075990756	SOD1	PITPNB
SOD1	PMP2	0.607890607	SOD1	PMP2
SOD1	LGALS3	0.121628662	SOD1	LGALS3
SOD1	STIP1	0.306323877	SOD1	STIP1
SOD1	LDHAL6A	0.467812993	SOD1	LDHAL6A
SOD1	COLEC10	0.089449078	SOD1	COLEC10
SOD1	FKBP7	0.085526041	SOD1	FKBP7
SOD1	MPI	0.121609726	SOD1	MPI
SOD1	ADSL	0.087440939	SOD1	ADSL
HIBADH	SOD1	0.100300904	HIBADH	SOD1
SOD1	PABPC3	0.079614581	SOD1	PABPC3
SOD1	ACY1	0.072748009	SOD1	ACY1
SOD1	LACTB2	0.08738011	SOD1	LACTB2
SOD1	GSTZ1	0.121376231	SOD1	GSTZ1
SOD1	AKR1B15	0.203035704	SOD1	AKR1B15

Metazoan complexes

Emili & Marcotte labs

Details of SOD1 gene in Homo sapiens

IDs

Disease

Phenotypes

Orthologs in other species