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Metazoan complexes |
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Details of mbd-2 gene in Caenorhabditis elegans
IDs | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Link outs | Gene Name | Alias | Uniprot ID | SwissProt ID | NCBI gene ID | W.Base gene ID | W.Base accession | Description | Source |
|
| mbd-2 | --- | Q6HAE8 | --- | --- | WBGene00023409 | C27A12.10 | mbd-2 encodes an truncated ortholog of methyl-CpG-binding-domain (MBD) proteins this is a surprising orthology, because C. elegans genomic DNA is unmethylated, and may reflect a more general role of MBD proteins in epigenetic regulation independent of methyl-DNA binding while mbd-2(RNAi) animals have no obvious phenotype, RNAi of the C. briggsae mbd-2 ortholog causes paralysis MBD-2 may be functionally analogous to MeCP2 proteins, which are required in nonmitotic neurons and deficient in the progressive autism Rett syndrome (OMIM:300005). | WORMBASE |
Phenotypes
Orthologs in other species | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| H. sapiens | M. musculus | D. melonogaster | S. purpuratus | ||||||
| MBD3L1 | Mbd3l1 | --- | --- | MBD3L2 | Mbd3l2 | --- | --- | MBD3L3 | Mbd3l2 | --- | --- | MBD3L4 | Mbd3l2 | --- | --- | MBD3L5 | Mbd3l2 | --- | --- | MBD2 | Mbd2 | MBD-like | --- | MBD3 | Mbd3 | MBD-like | --- |
| Conserved gene 1 |
Conserved gene 2 |
Conserved score |
C. elegans gene 1 |
C. elegans gene 2 |
Complex ID | Corum | BioGrid | IRefWeb | Novelty |
|---|---|---|---|---|---|---|---|---|---|
| Conserved gene 1 |
Conserved gene 2 |
Conserved score |
C. elegans gene 1 |
C. elegans gene 2 |
|---|---|---|---|---|