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Details of mbd-2 gene in Caenorhabditis elegans
IDs |
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| Link outs |
Gene Name |
Alias |
Uniprot ID |
SwissProt ID |
NCBI gene ID |
W.Base gene ID |
W.Base accession |
Description |
Source |
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| mbd-2 | --- | Q6HAE8 | --- | --- | WBGene00023409 | C27A12.10 | mbd-2 encodes an truncated ortholog of methyl-CpG-binding-domain (MBD) proteins
this is a surprising orthology, because C. elegans genomic DNA is unmethylated, and may reflect a more general role of MBD proteins in epigenetic regulation independent of methyl-DNA binding
while mbd-2(RNAi) animals have no obvious phenotype, RNAi of the C. briggsae mbd-2 ortholog causes paralysis
MBD-2 may be functionally analogous to MeCP2 proteins, which are required in nonmitotic neurons and deficient in the progressive autism Rett syndrome (OMIM:300005). | WORMBASE |
Phenotypes
Orthologs in other species |
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| H. sapiens |
M. musculus |
D. melonogaster |
S. purpuratus |
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