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Details of ssu-1 gene in Caenorhabditis elegans
IDs |
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Gene Name |
Alias |
Uniprot ID |
SwissProt ID |
NCBI gene ID |
W.Base gene ID |
W.Base accession |
Description |
Source |
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| ssu-1 | --- | Q9U2Z2 | Q9U2Z2_CAEEL | --- | WBGene00013748 | Y113G7A.11 | ssu-1 encodes, by alternative splicing, two isoforms of a cytosolic alcohol sulfotransferase that interacts in the ASJ amphid neurons with the stomatins UNC-1 and UNC-24
the longer SSU-1 isoform is required for normal anesthetic sensitivity and unc-1 phenotypes
ssu-1(fc73) suppresses the anesthetic sensitivity and uncoordinated phenotypes of unc-1 and unc-24 mutants
ssu-1(fc73), along with daf-12, suppresses the synthetic constitutive dauer-formation phenotype of fc83
unc-24(e138) mutants
ssu-1 suppression is rescued by transgenic expression of SSU-1 in the ASJ neurons alone, implying that sulfation is required for an endocrine function
SSU-1 protein sulfates 4-nitrophenol and 2-naphthol substrates, and bisphenol A, but not monoamines or hydroxysteroids
SSU-1 is cytosolic, but its activity is not detectable in cytosolic extracts
ssu-1 is strongly expressed in embryos, growing larvae, and dauer larvae
ssu-1 expression is increased in daf-2
by homology with other sulfotransferases, SSU-1 may link sulfates to the alcohol group of small molecules as part of detoxification or signal transduction. | WormBase |
Phenotypes
Orthologs in other species |
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| H. sapiens |
M. musculus |
D. melonogaster |
S. purpuratus |
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