Metazoan complexes |
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Emili & Marcotte labs |
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Details of ssu-1 gene in Caenorhabditis elegans
IDs | |||||||||
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Link outs | Gene Name | Alias | Uniprot ID | SwissProt ID | NCBI gene ID | W.Base gene ID | W.Base accession | Description | Source |
| ssu-1 | --- | Q9U2Z2 | Q9U2Z2_CAEEL | --- | WBGene00013748 | Y113G7A.11 | ssu-1 encodes, by alternative splicing, two isoforms of a cytosolic alcohol sulfotransferase that interacts in the ASJ amphid neurons with the stomatins UNC-1 and UNC-24 the longer SSU-1 isoform is required for normal anesthetic sensitivity and unc-1 phenotypes ssu-1(fc73) suppresses the anesthetic sensitivity and uncoordinated phenotypes of unc-1 and unc-24 mutants ssu-1(fc73), along with daf-12, suppresses the synthetic constitutive dauer-formation phenotype of fc83 unc-24(e138) mutants ssu-1 suppression is rescued by transgenic expression of SSU-1 in the ASJ neurons alone, implying that sulfation is required for an endocrine function SSU-1 protein sulfates 4-nitrophenol and 2-naphthol substrates, and bisphenol A, but not monoamines or hydroxysteroids SSU-1 is cytosolic, but its activity is not detectable in cytosolic extracts ssu-1 is strongly expressed in embryos, growing larvae, and dauer larvae ssu-1 expression is increased in daf-2 by homology with other sulfotransferases, SSU-1 may link sulfates to the alcohol group of small molecules as part of detoxification or signal transduction. | WormBase |
Phenotypes
embryonic lethal, lethal, maternal sterile, organism morphology variant, postembryonic development variant, Variant.
Orthologs in other species | |||||||||
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H. sapiens | M. musculus | D. melonogaster | S. purpuratus | ||||||
SULT1A1 | Sult1a1 | St1... | Sp-Sult1_1... | SULT1A2 | Sult1a1 | St1... | Sp-Sult1_1... | SULT1A4 | Sult1a1 | St1... | Sp-Sult1_1... | SULT1B1 | Sult1b1 | St1... | Sp-Sult1_1... | SULT1C2 | Sult1c2 | St1... | Sp-Sult1_1... | SULT1C3 | Sult1c1 | St1... | Sp-Sult1_1... | SULT1C4 | --- | St1... | Sp-Sult1_1... | SULT1E1 | ENSMUSG00000029272 | St2 | Sp-Sult1_1... | SULT2A1 | Sult2a1... | St1... | --- | SULT2B1 | Sult2b1 | St1... | --- |
Conserved gene 1 |
Conserved gene 2 |
Conserved score |
C. elegans gene 1 |
C. elegans gene 2 |
Complex ID | Corum | BioGrid | IRefWeb | Novelty |
---|---|---|---|---|---|---|---|---|---|
Conserved gene 1 |
Conserved gene 2 |
Conserved score |
C. elegans gene 1 |
C. elegans gene 2 |
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