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Details of MCM4 gene in Homo sapiens
IDs | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Link outs | Gene Name | Alias | Uniprot ID | SwissProt ID | NCBI gene ID | ENSEMBL ID | Description | Source | |
|
| MCM4 | CDC21 | P33991 | MCM4_HUMAN | 4173 | ENSG00000104738 | DNA replication licensing factor MCM4 | SPROT | |
Disease | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Disease | OMIM id | ||||||||
| Natural killer cell and glucocorticoid deficiency with DNA repair defect (NKGCD) [MIM:609981]: An autosomal recessive disorder characterized by severe intra- and extrauterine growth retardation, microcephaly, decreased numbers of natural killer cells, and recurrent viral infections, most often affecting the respiratory tract and leading to respiratory failure. Affected individuals also have adrenal insufficiency requiring corticosteroid replacement therapy and may have an increased susceptibility to cancer. Note=The disease is caused by mutations affecting the gene represented in this entry. | 609981 | ||||||||
Orthologs in other species | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| M. musculus | D. melonogaster | C. elegans | S. purpuratus | ||||||
| Mcm4 | dpa | mcm-4 | Sp-Mcm | ||||||
| Conserved gene 1 |
Conserved gene 2 |
Conserved score |
H. sapiens gene 1 |
H. sapiens gene 2 |
Complex ID | Corum | BioGrid | IRefWeb | Novelty |
|---|---|---|---|---|---|---|---|---|---|
| MCM4 | MCM3 | 1 | MCM4 | MCM3 | cpx98 | yes | yes | yes | Known |
| MCM2 | MCM4 | 1 | MCM2 | MCM4 | cpx98 | yes | yes | yes | Known |
| MCM5 | MCM4 | 1 | MCM5 | MCM4 | cpx98 | yes | yes | yes | Known |
| MCM4 | MCM6 | 1 | MCM4 | MCM6 | cpx98 | yes | yes | yes | Known |
| MCM4 | MCM7 | 1 | MCM4 | MCM7 | cpx98 | yes | yes | yes | Known |
| Conserved gene 1 |
Conserved gene 2 |
Conserved score |
H. sapiens gene 1 |
H. sapiens gene 2 |
|---|---|---|---|---|
| MCM4 | MAPRE2 | 0.131955112 | MCM4 | MAPRE2 |
| MCM4 | SF3A1 | 0.105977669 | MCM4 | SF3A1 |
| MCM4 | RAD21 | 0.077016245 | MCM4 | RAD21 |
| MCM4 | SF3B2 | 0.084299578 | MCM4 | SF3B2 |
| MCM4 | SF3B1 | 0.192122924 | MCM4 | SF3B1 |
| SAFB | MCM4 | 0.093251498 | SAFB | MCM4 |
| MCM4 | TRIP10 | 0.102752567 | MCM4 | TRIP10 |
| MCM4 | SF3A3 | 0.07333117 | MCM4 | SF3A3 |
| MCM4 | SLC4A1AP | 0.124184123 | MCM4 | SLC4A1AP |
| MCM4 | KPNA4 | 0.077886439 | MCM4 | KPNA4 |
| MCM4 | INPPL1 | 0.109865491 | MCM4 | INPPL1 |