Metazoan complexes |
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Emili & Marcotte labs |
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Details of TPR gene in Homo sapiens
IDs | |||||||||
---|---|---|---|---|---|---|---|---|---|
Link outs | Gene Name | Alias | Uniprot ID | SwissProt ID | NCBI gene ID | ENSEMBL ID | Description | Source | |
| TPR | --- | P12270 | TPR_HUMAN | 7175 | ENSG00000047410 | Nucleoprotein TPR | SPROT |
Disease | |||||||||
---|---|---|---|---|---|---|---|---|---|
Disease | OMIM id | ||||||||
Thyroid papillary carcinoma (TPC) [MIM:188550]: A common tumor of the thyroid that typically arises as an irregular, solid or cystic mass from otherwise normal thyroid tissue. Papillary carcinomas are malignant neoplasm characterized by the formation of numerous, irregular, finger-like projections of fibrous stroma that is covered with a surface layer of neoplastic epithelial cells. Note=The gene represented in this entry is involved in disease pathogenesis. A chromosomal aberration involving TPR has been found in thyroid papillary carcinomas. Intrachromosomal rearrangement that links the 5'-end of the TPR gene to the protein kinase domain of NTRK1 forms the fusion protein TRK-T1. TRK-T1 is a 55 kDa protein reacting with antibodies against the carboxy terminus of the NTRK1 protein. | 188550 | Note=Involved in tumorigenic rearrangements with the MET or RAF genes. | 188550 |
Orthologs in other species | |||||||||
---|---|---|---|---|---|---|---|---|---|
M. musculus | D. melonogaster | C. elegans | S. purpuratus | ||||||
Tpr | Mtor | npp-21 | --- |
Conserved gene 1 |
Conserved gene 2 |
Conserved score |
H. sapiens gene 1 |
H. sapiens gene 2 |
Complex ID | Corum | BioGrid | IRefWeb | Novelty |
---|---|---|---|---|---|---|---|---|---|
Conserved gene 1 |
Conserved gene 2 |
Conserved score |
H. sapiens gene 1 |
H. sapiens gene 2 |
---|---|---|---|---|
TPR | EEF1D | 0.083504955 | TPR | EEF1D |
TPR | NUP107 | 0.09301547 | TPR | NUP107 |
MRE11A | TPR | 0.081942299 | MRE11A | TPR |
TPR | RRP12 | 0.078508977 | TPR | RRP12 |
TPR | STIP1 | 0.075905014 | TPR | STIP1 |
TPR | GLRX | 0.076403017 | TPR | GLRX |
NXF1 | TPR | 0.174335562 | NXF1 | TPR |
TPR | ATL3 | 0.072077709 | TPR | ATL3 |
TPR | SRSF11 | 0.104190872 | TPR | SRSF11 |