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Details of GPI gene in Homo sapiens
IDs | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Link outs | Gene Name | Alias | Uniprot ID | SwissProt ID | NCBI gene ID | ENSEMBL ID | Description | Source | |
|
| GPI | --- | P06744 | G6PI_HUMAN | 2821 | ENSG00000105220 | Glucose-6-phosphate isomerase | SPROT | |
Disease | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Disease | OMIM id | ||||||||
| Hemolytic anemia, non-spherocytic, due to glucose phosphate isomerase deficiency (HA-GPID) [MIM:613470]: A form of anemia in which there is no abnormal hemoglobin or spherocytosis. It is caused by glucose phosphate isomerase deficiency. Note=The disease is caused by mutations affecting the gene represented in this entry. | 613470 | ||||||||
Phenotypes
Abnormality of blood and blood-forming tissues, Abnormality of carbohydrate metabolism/homeostasis, Abnormality of central motor function, Abnormality of coordination, Abnormality of erythrocytes, Abnormality of glycolysis, Abnormality of higher mental function, Abnormality of metabolism/homeostasis, Abnormality of muscle physiology, Abnormality of the abdomen, Abnormality of the abdominal organs, Abnormality of the biliary system, Abnormality of the central nervous system, Abnormality of the cerebellum, Abnormality of the gallbladder, Abnormality of the hindbrain, Abnormality of the immune system, Abnormality of the integument, Abnormality of the liver, Abnormality of the lymphatic system, Abnormality of the metencephalon, Abnormality of the musculature, Abnormality of the nervous system, Abnormality of the skin, Abnormality of the spleen, All, Anemia, Anemia due to reduced life span of red cells, Ataxia, Autosomal dominant inheritance, Cholecystitis, Cholelithiasis, Cholestasis, Cognitive impairment, Decreased glucosephosphate isomerase activity, Dermatological manifestations of systemic disorders, Generalized abnormality of skin, Hemolytic anemia, Intellectual disability, Jaundice, Mode of inheritance, Morphological abnormality of the central nervous system, Muscle weakness, Nonspherocytic hemolytic anemia, Phenotypic abnormality, Splenomegaly, Spontaneous hemolytic crises, Visceromegaly.
Orthologs in other species | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| M. musculus | D. melonogaster | C. elegans | S. purpuratus | ||||||
| Gpi | Pgi | gpi-1 | Sp-Gpi... | ||||||
| Conserved gene 1 |
Conserved gene 2 |
Conserved score |
H. sapiens gene 1 |
H. sapiens gene 2 |
Complex ID | Corum | BioGrid | IRefWeb | Novelty |
|---|---|---|---|---|---|---|---|---|---|
| GPI | ANXA7 | 0.321997892 | GPI | ANXA7 | cpx212 | no | no | no | Novel |
| GPI | FH | 0.173504591 | GPI | FH | cpx40 | no | no | yes | Known |
| GOT2 | GPI | 0.182667971 | GOT2 | GPI | cpx980 | no | no | no | Novel |
| LDHB | GPI | 0.039764783 | LDHB | GPI | cpx40 | no | no | no | Novel |
| TKT | GPI | 0.221705087 | TKT | GPI | cpx40 | no | no | no | Novel |
| PRDX6 | GPI | 0.07699437 | PRDX6 | GPI | cpx914 | no | no | no | Novel |
| LDHA | GPI | 0.027446746 | LDHA | GPI | cpx40 | no | no | no | Novel |
| LACTB2 | GPI | 0.101000023 | LACTB2 | GPI | cpx980 | no | no | no | Novel |
| ENO1 | GPI | 0.118015698 | ENO1 | GPI | cpx40 | no | no | no | Novel |
| CAT | GPI | 0.045835841 | CAT | GPI | cpx40 | no | no | no | Novel |
| GPI | TPI1 | 0.555239618 | GPI | TPI1 | cpx40; cpx212 | no | no | no | Novel |
| Conserved gene 1 |
Conserved gene 2 |
Conserved score |
H. sapiens gene 1 |
H. sapiens gene 2 |
|---|---|---|---|---|
| GPI | PEF1 | 0.139180468 | GPI | PEF1 |
| GPI | DCXR | 0.089791886 | GPI | DCXR |
| AKR1A1 | GPI | 0.09443656 | AKR1A1 | GPI |
| GPI | ALDH4A1 | 0.093288789 | GPI | ALDH4A1 |
| WDR1 | GPI | 0.075815842 | WDR1 | GPI |
| PGM1 | GPI | 0.089891826 | PGM1 | GPI |
| PGM5 | GPI | 0.096344595 | PGM5 | GPI |
| MRPL45 | GPI | 0.078510988 | MRPL45 | GPI |
| SDHB | GPI | 0.165534356 | SDHB | GPI |
| RAB10 | GPI | 0.079027335 | RAB10 | GPI |
| SORD | GPI | 0.082285624 | SORD | GPI |
| ABAT | GPI | 0.073551912 | ABAT | GPI |
| ESD | GPI | 0.081076717 | ESD | GPI |