Metazoan Gene Interaction Project

	Metazoan complexes
	Emili & Marcotte labs

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IDs
Link outs	Gene Name	Alias	Uniprot ID	SwissProt ID	NCBI gene ID	Fly Base ID	Description	Source
	N	---	P07207	NOTCH_DROME	31293	FBgn0004647	Neurogenic locus Notch protein Processed neurogenic locus Notch protein	SPROT

Orthologs in other species
H. sapiens	M. musculus	C. elegans	S. purpuratus
NOTCH1	Notch1	glp-1... lin-12	SPU_014131
NOTCH2	Notch2	glp-1... lin-12	SPU_014131

Conserved gene 1	Conserved gene 2	Conserved score	D. melanogaster gene 1	D. melanogaster gene 2	Complex ID	Corum	BioGrid	IRefWeb	Novelty
CDC42	NOTCH2	0.190508398	Cdc42	N	cpx301; cpx162	no	no	no	Novel

Metazoan complexes

Emili & Marcotte labs

Details of N gene in Drosophila melanogaster

IDs

Orthologs in other species

Conserved gene 1	Conserved gene 2	Conserved score	D. melanogaster gene 1	D. melanogaster gene 2
SND1	TXNDC5	0.077480763	prtp	Tudor-SN
NUP214	DYNC1LI1	0.150280461	Nup214	Dlic
MARS	NMT1	0.07288836	CG15100	Nmt
NOP10	NHP2	0.190621078	FBgn0033548	NHP2
NDUFS8	CYC1	0.181639922	ND23	CG4769
NSF	RAP2A	0.085971795	Nsf2, comt	Rap2l
RAN	NUTF2	0.706539906	ran	Ntf-2
DKC1	NOC2L	0.098867829	Nop60B	FBgn0032925
NUCB2	SPTAN1	0.079449076	NUCB1	alpha-Spec
POLE	PABPC4	0.115146248	DNApol-epsilon	pAbp
EIF5B	NHP2	0.074622845	eIF5B	NHP2
CDC6	POLA1	0.11645374	Cdc6	DNApol-alpha180
SF3A3	SNRNP70	0.175314573	noi	snRNP-U1-70K
NDUFA10	NDUFS2	0.130989182	ND42	CG1970
PGAM2	NUTF2	0.099270969	Pglym78, Pglym87	Ntf-2
AP2B1	NUP50	0.08282979	Bap	Nup50
DIMT1	DKC1	0.227202047	FBgn0039627	Nop60B
PPA2	PPP1R11	0.133761544	Nurf-38	CG13994
SF3A3	COPS3	0.124309694	noi	CSN3
EIF4G1	NUP50	0.089617191	eIF4G	Nup50
DR1	CCDC101	0.130406205	NC2beta	Sgf29
DKC1	UQCRC2	0.076884734	Nop60B	CG4169
GLO1	PPA1	0.071103385	Nurf-38	CG1707
NUP50	PFDN4	0.077534614	Nup50	FBgn0035603
SNRNP200	RANBP2	0.088039325	FBgn0036548	Nup358
NFYC	CORO1C	0.080741153	Nf-YC	coro
NOP56	GLYR1	0.071610314	Nop56	FBgn0043456
TAGLN2	NUTF2	0.103218144	Chd64, CG5023	Ntf-2
KIAA0020	DKC1	0.162624312	pen	Nop60B
NOP56	PES1	0.108735116	Nop56	FBgn0032138
RUVBL1	TRRAP	0.088215593	pont	Nipped-A
NPM3	ATP5B	0.243326332	Nlp, CG7911	ATPsyn-beta
NOP56	SMARCA4	0.199767416	Nop56	brm
CHCHD2	PPA2	0.072454402	CG5010	Nurf-38
P4HB	NACA2	0.732137668	Pdi	Nacalpha
COPS5	EIF3F	0.089959388	CSN5	eIF3-S5-1
NASP	DKC1	0.070722981	FBgn0037624	Nop60B
KCNAB2	NUTF2	0.085249237	CG3397, CG18547, CG12224	Ntf-2
NOP56	FTSJ3	0.809600288	Nop56	CG8939
TPR	NUP107	0.09301547	Mtor	Nup107
WBSCR22	NMD3	0.073393399	CG10903	Nmd3
NLE1	GBE1	0.079461152	Nle	CG33138
NUDT9	NIT1	0.11613769	CG4098	NitFhit
KIAA0020	NOP56	0.119050436	pen	Nop56
NUP50	FLNB	0.094671808	Nup50	cher
NUTF2	APOA1BP	0.099102913	Ntf-2	FBgn0030178
ATP2A2	NOTCH2	0.074210356	Ca-P60A	N
NOP56	ABCF2	0.120133249	Nop56	CG9281
SUPT16H	NAP1L1	0.073213867	dre4	Nap1
VDAC3	NDUFS8	0.070828717	porin	ND23
SNRNP70	ARGLU1	0.175587103	snRNP-U1-70K	FBgn0051712
FKBP14	PPA2	0.184856019	Fkbp13	Nurf-38
NDUFA10	COX5B	0.098444879	ND42	CoVb
SOD1	NUTF2	0.271992833	Sod	Ntf-2
DDX18	NOP56	0.826911729	pit	Nop56
SNRNP70	PRPF19	0.220324205	snRNP-U1-70K	Prp19
NUTF2	HINT1	0.135647067	Ntf-2	CG2862
DKC1	GTPBP4	0.094371009	Nop60B	FBgn0028473
OGDH	COX5A	0.101857878	Nc73EF	CoVa
NOP56	DDX27	0.248460639	Rs1	Nop56
EIF3H	COPS5	0.092612263	eIF-3p40	CSN5
BCAP29	NACA2	0.095963227	CG13887	Nacalpha
UTP14A	DKC1	0.103911024	CG12301	Nop60B
PSMD12	NAA16	0.096692285	Rpn5	Nat1
NF1	NOSIP	0.080059789	Nf1	FBgn0030915
POLE	PABPC1	0.102903224	DNApol-epsilon	pAbp
NUP50	PAIP1	0.07539096	Nup50	CG8963
MPHOSPH10	DKC1	0.074656671	CG13097	Nop60B
NDUFS1	AFG3L2	0.076485292	ND75	CG6512
PPP1R8	SHC1	0.09604651	NiPp1	Shc
NUP50	PSME3	0.119688611	Nup50	REG
NFYB	CORO1B	0.083262074	Nf-YB	coro
CYCS	NLE1	0.096029474	Cyt-c-p	Nle
PFDN2	NUP50	0.082404544	l(3)01239	Nup50
NOP56	EBNA1BP2	0.119672003	Nop56	FBgn0039828
POLA2	SCYL1	0.074715865	DNApol-alpha73	yata
RDX	PPA1	0.07443204	Moe	Nurf-38
DHX15	DKC1	0.209026698	CG11107	Nop60B
CDC16	NAP1L4	0.122654925	cdc16	Nap1
DKC1	TBL3	0.07866547	Nop60B	CG1671
VCP	NSF	0.115320236	TER94	Nsf2, comt
NEDD8	NIT1	0.084030185	Nedd8	NitFhit
RANBP2	UQCRC2	0.130632408	Nup358	CG4169
PCNA	POLE	0.076568095	mus209	DNApol-epsilon
SLC25A3	NDUFS1	0.254734357	ND75	CG9090
NEDD8	ATP6V1F	0.09813276	Nedd8	Vha14-1
NMD3	PUS1	0.207913668	Nmd3	CG4159
AIP	PPA2	0.169104181	CG1847	Nurf-38
NEDD8	MEMO1	0.114980051	Nedd8	CG8031
HNRNPR	NAA15	0.08562209	CG17838	Nat1
SMARCA5	COPS3	0.084368928	Iswi	CSN3
ATP1B3	OGDH	0.08888211	Nc73EF	nrv2
TPD52	NACA2	0.209496769	CG5174	Nacalpha
KIF11	SNRNP70	0.104887712	Klp61F	snRNP-U1-70K
NSF	ATP6V0D1	0.0776766	Nsf2, comt	VhaAC39-1
EIF4A1	NFYB	0.109792239	eIF-4a	Nf-YB
NDUFS2	OGDH	0.114903207	Nc73EF	CG1970
PPA1	ITPA	0.074006315	Nurf-38	FBgn0031663
PSMD14	COPS6	0.07272865	Rpn11	CSN6
CRNKL1	SNRNP70	0.076940084	crn	snRNP-U1-70K
TRRAP	BTAF1	0.076243545	Nipped-A	Hel89B
NPM3	ARGLU1	0.098614883	Nlp	FBgn0051712
SNRNP70	PRPF8	0.547318716	snRNP-U1-70K	Prp8
PPP1R8	SNUPN	0.084648866	NiPp1	CG42303
MCM3	NUP62	0.189200637	Mcm3	Nup62
PRIM1	RPA2	0.163802586	DNApol-alpha50	RPA2
NAP1L1	PES1	0.207164989	Nap1	FBgn0032138
GTF2B	NAP1L1	0.090564458	TfIIB	Nap1
NUP50	CCDC22	0.13077668	Nup50	FBgn0036671
FTSJ3	DKC1	0.09985077	CG8939	Nop60B
NOP56	ATAD3B	0.123485476	Nop56	bor
DDX24	NOP56	0.366618795	CG9143	Nop56
B4GALT3	ANP32A	0.073379333	beta4GalNAcTA	Anp32a
NUP98	TNPO1	0.119034511	Nup98-96	Trn
SNRNP70	PRPF40A	0.097053378	snRNP-U1-70K	CG3542
CALU	NACA2	0.077437979	scf	Nacalpha
NSF	VPS4B	0.139115427	Nsf2, comt	Vps4
NDUFS1	MT-CO2	0.091761078	mt:CoII	ND75
EIF2S2	NOP56	0.096060989	eIF-2beta	Nop56
AIP	PPA1	0.103196376	CG1847	Nurf-38
NMD3	DIS3	0.090764782	Nmd3	Dis3
POLE	MSH6	0.164644213	DNApol-epsilon	Msh6
DKC1	EIF5B	0.607717979	Nop60B	eIF5B
TLE3	PPA1	0.085119174	gro	Nurf-38
NDUFA10	COX4I1	0.088446922	ND42	CoIV
SEH1L	NUP98	0.102434609	Nup44A	Nup98-96
NOP56	NOL6	0.187427694	Nop56	Mat89Ba
PRPF8	RANBP2	0.129184137	Prp8	Nup358
RANBP2	IPO5	0.08712702	Nup358	Karybeta3
DKC1	RPF2	0.078979898	Nop60B	FBgn0038585
UTP14A	NOP56	0.174312805	CG12301	Nop56
NUP50	STXBP1	0.097963931	Nup50	Rop
EZR	PPA2	0.078764	Moe	Nurf-38
SSRP1	NAP1L1	0.136768917	Ssrp	Nap1
NOP56	SMARCA2	0.128290549	Nop56	brm
DHX9	NAA15	0.079963254	mle	Nat1
NOP56	SSB	0.08363354	Nop56	La
NOP56	NSA2	0.187371649	Ip259	Nop56
NDUFS1	TECR	0.100956069	ND75	Sc2
NUTF2	PRCP	0.0886632	Ntf-2	CG2493
NOP56	GTPBP4	0.480601918	FBgn0028473	Nop56
HMGCS1	NEDD8	0.096869879	Hmgs	Nedd8
TAGLN	NUTF2	0.07529548	Chd64, CG5023	Ntf-2
OGDH	CYC1	0.089937501	Nc73EF	CG4769
CTSD	SCNN1G	0.175341075	cathD, CG10104	ppk16, Nach, ppk11, CG31105, ppk7
SLC25A3	NDUFS8	0.121519211	ND23	CG9090
SNRPD3	SNRNP70	0.074604577	SmD3	snRNP-U1-70K
PSMD4	POLE	0.101161941	Pros54	DNApol-epsilon
EIF4G1	POLE	0.186908807	eIF4G	DNApol-epsilon
NMD3	RFC5	0.072675132	Nmd3	RfC3
NPM3	EEF1G	0.11278205	Nlp, CG7911	Ef1gamma
COPS7A	PSMD12	0.086895063	CSN7	Rpn5
PGAM1	NUTF2	0.102145476	Pglym78, Pglym87	Ntf-2
NUP50	NARS	0.085593135	Nup50	Aats-asn
NDUFS1	GNB2	0.071394988	Gbeta13F	ND75
NOTCH2	PDIA6	0.101709776	N	CaBP1
RAN	RANBP2	0.074907004	ran	Nup358
PRPF3	SNRNP70	0.170173273	CG7757	snRNP-U1-70K
ATP1B1	NDUFS1	0.24476952	nrv2	ND75
SSB	POLE	0.227323033	La	DNApol-epsilon
CAND2	NAA15	0.138036518	Cand1	Nat1
KPNB1	NUP98	0.179399795	Fs(2)Ket	Nup98-96
PBRM1	COPS3	0.079957625	polybromo	CSN3
NOP56	WDR36	0.173759089	Nop56	CG9799
FBL	NAA15	0.10306578	Fib	Nat1
NDUFB10	NDUFS1	0.234473765	ND75	Pdsw
NOP56	DDX56	0.517419455	Hlc	Nop56
HSP90AB1	NPM3	0.104247297	Hsp83	Nlp, CG7911
NOP2	DKC1	0.214631809	CG8545	Nop60B
COPS4	EIF3M	0.162918812	CSN4	Tango7
XPNPEP1	NUTF2	0.152743893	ApepP	Ntf-2
OGDH	ATP5H	0.164540995	Nc73EF	ATPsyn-d
NEDD8	PRDX5	0.074431883	Nedd8	Prx5
SKIV2L2	LIG1	0.077490433	l(2)35Df	DNA-ligI
NOP56	RPS7	0.199305241	Nop56	RpS7
SNRNP70	TFIP11	0.229158687	snRNP-U1-70K	sip1
PCNA	NACA2	0.244662164	mus209	Nacalpha
MTHFD2	CLIC1	0.081921667	Nmdmc	Clic
NOTCH2	MLLT4	0.07352505	N	cno
ALYREF	NAP1L1	0.070424372	Ref1	Nap1
FKBP7	PPA1	0.085754109	Fkbp13	Nurf-38
SDHB	NDUFS1	0.4532568	SdhB	ND75
UFM1	PPA2	0.072206349	FBgn0085220	Nurf-38
RANBP2	NXF1	0.5	Nup358	sbr
PPA1	C11orf54	0.078650516	Nurf-38	CG32335
CLIP1	GPS1	0.071536149	CLIP-190	CSN1b
LDHB	NUP50	0.074501263	ImpL3	Nup50
PSMD12	NAA15	0.157592427	Rpn5	Nat1
SLC12A2	GNG12	0.084143562	Ncc69	Ggamma1, CG43324
NUTF2	AP2A2	0.124129469	alpha-Adaptin	Ntf-2
XPO5	NUP98	0.148405074	Ranbp21	Nup98-96
DKC1	BCCIP	0.090000721	Nop60B	FBgn0038183
NUP153	RAN	0.088154485	Nup153	ran
TAGLN3	NUTF2	0.169669911	Chd64, CG5023	Ntf-2
NMD3	NOP58	0.125955338	Nmd3	nop5
NPM3	YWHAE	0.225639357	Nlp, CG7911	14-3-3epsilon
NOP56	BRIX1	0.332206028	Nop56	CG11583
SNRPC	CARM1	0.083040189	snRNP-U1-C	Art4
ACOX1	NUP62	0.100866595	FBgn0027572, Acox57D-p, Acox57D-d, CG4586	Nup62
NDUFA10	NDUFV1	0.144483199	ND42	CG9140
SKIV2L2	NLE1	0.075331561	l(2)35Df	Nle
NOP56	DHX15	0.5	Nop56	CG11107
DKC1	RPS4X	0.091460608	Nop60B	RpS4
RPLP0	RANBP2	0.140903892	RpLP0	Nup358
PABPC4	PPA1	0.076554847	pAbp	Nurf-38
NOP56	MKI67IP	0.143664999	Nop56	CG6937
NDUFS8	UQCRC2	0.084789629	ND23	CG4169
PPA2	TANGO2	0.088202575	Nurf-38	Tango2
NDUFS8	NDUFA12	0.220718968	ND23	CG3214
NUP50	HSPBP1	0.080262307	Nup50	CG10973
RANBP2	EFTUD2	0.183766159	Nup358	CG4849
NOP56	UTP18	0.081312223	Nop56	wcd
TOP2A	RANBP2	0.087139935	Top2	Nup358
ATP1B3	NDUFS1	0.217281183	nrv2	ND75
ABCF2	DKC1	0.078268637	CG9281	Nop60B
PPA2	DUT	0.08868805	Nurf-38	dUTPase
POLA1	POLE	0.432217243	DNApol-alpha180	DNApol-epsilon
PTGES3	RANBP2	0.108768305	FBgn0037728	Nup358
OGDH	NDUFS4	0.07624609	Nc73EF	CG12203
NFYB	LAGE3	0.124473333	Nf-YB	CG42498
DKC1	MKI67IP	0.074928489	Nop60B	CG6937
NUP133	ZMYM2	0.111977769	Nup133	woc
TAF4	NAP1L4	0.092451583	Taf4	Nap1
DDX18	DKC1	0.304979973	pit	Nop60B
DKC1	WDR36	0.287393233	Nop60B	CG9799
DDX27	DKC1	0.09185849	Rs1	Nop60B
RANBP2	VCP	0.077801098	Nup358	TER94
C9orf64	NEDD8	0.077869418	CG9752	Nedd8
SNRNP70	SRSF11	0.082940366	snRNP-U1-70K	Srp54
GARS	NUP50	0.103736697	Aats-gly	Nup50
PSMC3	NAA15	0.076682012	Tbp-1	Nat1
NAA15	NAA20	0.151126557	Nat1	CG14222
NUP85	NUP98	0.130300117	Nup75	Nup98-96
MED13	RANBP2	0.091767272	skd	Nup358
NOP56	TBL3	0.16110586	Nop56	CG1671
RANBP2	CLTC	0.114278764	Nup358	Chc
PCNA	POLA1	0.106541496	mus209	DNApol-alpha180
SMC1A	POLE	0.122976752	SMC1	DNApol-epsilon
RAB11B	NUTF2	0.136759692	Rab11	Ntf-2
DRG1	NAA15	0.089127975	128up	Nat1
NFYC	CORO1B	0.143992723	Nf-YC	coro
NOP56	KPNB1	0.158531685	Nop56	Fs(2)Ket
SNRNP70	RBM39	0.077939568	snRNP-U1-70K	CG11266
NUTF2	AP2A1	0.095636026	alpha-Adaptin	Ntf-2
NAP1L4	PES1	0.106582573	Nap1	FBgn0032138
ATP5F1	NDUFS1	0.19413243	ND75	ATPsyn-b
NDUFS1	NDUFA9	0.408510691	ND75	CG6020
OSGEP	NFYB	0.089599159	FBgn0036615	Nf-YB
NUTF2	GPX4	0.08503122	Ntf-2	PHGPx
PRPF40A	NPM3	0.077044079	CG3542	Nlp, CG7911
NSF	SCFD1	0.270666388	Nsf2, comt	Slh
RAB11A	NUTF2	0.102045834	Rab11	Ntf-2
STXBP1	PPP1R8	0.084254879	Rop	NiPp1
NDUFS8	AFG3L2	0.08375701	ND23	CG6512
SUCLG1	OGDH	0.164690585	Scsalpha	Nc73EF
KHSRP	NUP50	0.075032907	Psi	Nup50
NUP98	NUP107	0.405462807	Nup98-96	Nup107
NOP56	NOP2	0.147879795	Nop56	CG8545
NXF1	NXT1	0.631105271	sbr	Nxt1
NUP50	SBDS	0.080250828	Nup50	CG8549